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HRT patches may be safer than tablets researchers suggest

03/21/2015
02:42 | Author: Jack Phillips

Hrt patch
HRT patches may be safer than tablets researchers suggest

A study has found that women who use low doses of HRT through a patch to combat the symptoms of the menopause are at no greater risk of.

Women are usually recommended to take the lowest dose for the shortest time possible in order to relieve menopausal symptoms.

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In contrast women taking HRT tablets were on average 28 per cent more likely to have a stroke than those not on HRT, the study in the British Medical Journal found.

Overall there was a 28 per cent increased risk of stroke among the users of tablet HRT but the long-term tablet users were at a 35 per cent increased risk compared with women who had not taken it.

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Low-dose HRT patches carry 26 less risk than oral therapy Drug

03/21/2015
12:44 | Author: Victoria Roberts

Hrt patch
Low-dose HRT patches carry 26 less risk than oral therapy Drug

Hormone replacement therapy (HRT) skin patches containing low doses of estrogen carry less risk of stroke than oral therapy and may.

"It is also sufficiently large to evaluate the risk with lower and higher doses," he added.

Each case was matched to 59,958 controls. "The risk of stroke was not increased with use of low estrogen-dose patches compared with no use, whereas the risk was increased with high-dose patches," Dr Suissa said.

The study assessed the risk of stroke associated with HRT in post-menopausal women in the United Kingdom, using data from the General Practice Research Database (GPRD).

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Hormone replacement therapy (HRT) Topics, Menopause, Later life

03/21/2015
08:34 | Author: Jack Phillips

Hrt patch
Hormone replacement therapy (HRT) Topics, Menopause, Later life

Here women we interviewed talked about their experiences of HRT, how they saw its risks.. Carole tried in vain to find a HRT patch to suit.

I accept what they say but I’ve still got a niggling suspicion that it might have been, because I didn’t seem to be a high risk in any of the other ways that they described. They asked me all the questions and I didn’t really seem to come up with much of a risk factor in any of the other respects. I think given the choice, if I knew then what I know now, I probably wouldn’t have taken it but then other treatments didn’t exist when I was prescribed it so. They all think it’s very unlikely that that was the cause of it.

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Transdermal Hormone Replacement Therapy Patches for Women

03/21/2015
06:08 | Author: Caleb Parker

Hrt patch
Transdermal Hormone Replacement Therapy Patches for Women

Transdermal hormone replacement therapy (HRT) patches allow estradiol to be absorbed through the skin and released into the blood stream in metered doses.

Issue Postmenopausal symptoms can be treated with oral or transdermal HRT. Does the use of transdermal HRT patches, which are more expensive than oral HRT, offer advantages that offset the apparent economic disadvantage?.

The perspective was that of a third-party payer. Eligible studies compared the efficacy of transdermal HRT patches with oral HRT or with placebo patches.

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Low-dose HRT patches carry less risk of stroke than tablets, study

03/21/2015
04:30 | Author: Caleb Parker

Hrt patch
Low-dose HRT patches carry less risk of stroke than tablets, study

Hormone replacement therapy (HRT) skin patches containing low doses of oestrogen carry less risk of stroke than oral therapy and may.

Exposure to HRT was categorised into oestrogens only, oestrogens plus progestogen, progestogen only, and tibolone. Oestrogens were further subdivided according to the route of administration (oral or transdermal) and to the dose (high or low).

The above story is based on materials provided by BMJ-British Medical Journal. Note: Materials may be edited for content and length.

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Use of oral HRT increased the rate of stroke by around 25-30% compared with no use, regardless of the oestrogen dose or when combined with progestogen.

There was no risk increase with short-term use (less than one year) of the oral formulations, but longer-term users (more than one year) of the oral agents had a 35% increased risk.

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The risk of stroke was not increased with use of low oestrogen dose patches compared with no use, whereas the risk was increased by up to 88% with high dose patches.

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Their findings are based on data from the General Practice Research Database (GPRD), which holds the anonymised medical records of millions of patients registered with family doctors across the UK.

They add: "Although these results alone do not represent definitive evidence to promote the use of the transdermal route over oral administration of oestrogen replacement therapy, this study should encourage further research on the importance of the route of administration to define the role of transdermal oestrogens in the therapeutic arsenal for the treatment of menopausal symptoms." Story Source:

Hormone replacement therapy (HRT) skin patches containing low doses of oestrogen carry less risk of stroke than oral therapy and may represent a safer alternative to tablets, suggests a study published online in the British Medical Journal.

So researchers in Canada and Germany assessed the risk of stroke associated with oral and transdermal (through the skin) HRT in post-menopausal women in the UK.

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There is also evidence that different routes of administering HRT may be associated with a different risk of cerebrovascular events.

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