10 This suggests that its benefits are unlikely to be dramatic. A study comparing progesterone cream and soy milk showed that they had comparable benefits, but that used together they interfered with each other. Whether progesterone cream can prevent post-menopausal bone loss is still an open question — studies have reported that it can 20 and others have reported that it can’t. 20 Therefore, it is probably best not to use soy milk if you are using progesterone cream for osteoporosis. But even modest improvements in bone strength are important and worth pursuing.
1996 Aug; 11(8):1602-5 Mochtar MH, Hogerzeil HV, Mol BW. Progesterone alone versus progesterone combined with HCG as luteal support in GnRHa/HMG induced IVF cycles: a randomized clinical trial. Hum Reprod.
2005 Jun; 45(6):614-9 Hermann AC, Nafziger AN, Victory J, Kulawy R, Rocci ML, Bertino JS. Over-the-counter progesterone cream produces significant drug exposure compared to a Food and Drug Administration-approved oral progesterone product. J Clin Pharmacol.
Effect of progesterone therapy on arginine vasopressin and atrial natriuretic factor in premenstrual syndrome. Clin Invest Med. 1997 Aug; 20(4):211-23 Watanabe H, Lau DC, Guyn HL, Wong NL.
For some women progesterone administration can worsen mood if taken during the second half of the menstrual cycle, or improve it if taken during first half. 6 Some experimentation may be necessary to find an appropriate dosing schedule.
Exp Clin Psychopharmacol. 2007 Oct; 15(5):427-44 Goletiani NV, Keith DR, Gorsky SJ. Progesterone: review of safety for clinical studies.
13 But other studies have found the exact opposite. 21 The medical literature is full of such contradictions, which result from sloppy research work, differing dosages, or other factors. Fortunay, it’s easy enough to test the idea for oneself — if progesterone cream makes your breast pain go away without causing undesired side effects, then it’s “right for you”. Breast pain associated with menstrual cycle has been found in some studies to be greatly reduced with progesterone cream.
2008 Mar 1; :760-70 Nelson HD. Lancet. Menopause.
Accordingly, we will limit our discussion of Progesterone Cream to a brief summary of relevant research, and let you draw your own conclusions about what medical conditions it may be effective in treating.
Effects and side-effects of 2% progesterone cream on the skin of peri- and postmenopausal women: results from a double-blind, vehicle-controlled, randomized study. Br J Dermatol. 2005 Sep; 153(3):626-34 Holzer G, Riegler E, Hönigsmann H, Farokhnia S, Schmidt JB, Schmidt B.
A clinical trial at the University Federico II of Naples, Italy, showed that progesterone treatment produced a complete regression of this condition in 90.5% of the patients who used it, of which 78.3% occurred in the first 3 months and 11.5% after 6 months of treatment. Endometrial hyperplasia is a pre-cancerous condition of the endometrium in which the lining of the uterus becomes too thick, which results in abnormal bleeding.
Is Progesterone Cream useful for the conditions and purposes mentioned above? We aren’t allowed to l you, so you should take a look at some of the references cited here, and then decide for yourself.
Progesterone performs a number of functions in the body, some of them involving cardiovascular processes, cell division, temperature control, muscle relaxation, inflammation, and fat metabolism, and others involving the female monthly cycle and pregnancy. It is therefore not surprising that progesterone supplements can be used, regardless of gender, to achieve a wide variety of effects in the body.
Psychoneuroendocrinology. Sex steroid induced negative mood may be explained by the paradoxical effect mediated by GABA(A) modulators. 2009 Sep; 34(8):1121-32 Andréen L, Nyberg S, Turkmen S, vanWingen G, Fernández G, Bäckström T.
Prog Brain Res. Progesterone as a neuroprotective factor in traumatic and ischemic brain injury. 2009; 175:219-37 Sayeed I, Stein DG.
Although progesterone can be administered in various forms, LifeLink has chosen a 2.1% progesterone cream for its product line because of the ease and flexibility of application. 19. Progesterone is absorbed well transdermally 18 — in fact, transdermal creams have been shown to be just as effective as oral formulations.
Medical research has found evidence for progesterone’s effectiveness in the following applications:
1989 Apr 8; :931 McFadyen IJ, Raab GM, Macintyre CC, Forrest AP Synonyms: Dehydroepiandrosterone, prasterone. BMJ. Progesterone cream for cyclic breast pain.
9. Fluid retention is another symptom seen in Premenstrual Syndrome. In a clinical study conducted at the University of Calgary in 1997 a symptomatic improvement was achieved using progesterone.
Prevention of coronary hyperreactivity in preatherogenic menopausal rhesus monkeys by transdermal progesterone. 2004 May; 24(5):955-61 Hermsmeyer RK, Mishra RG, Pavcnik D, Uchida B, Axthelm MK, Stanczyk FZ, Burry KA, Illingworth DR, Juan C, Nordt FJ. Arterioscler Thromb Vasc Biol.
Double-blind controlled trial of progesterone vaginal cream treatment for cyclical mastodynia in women with benign breast disease. 1992 Dec; 15(11):801-6 Nappi C, Affinito P, DiCarlo C, Esposito G, Montemagno U. J Endocrinol Invest.
8 Researchers at the Emory University School of Medicine, USA, have suggested that a combination of progesterone and vitamin D3 — another neuroprotective supplement — should provide even better recovery for brain injuries than either supplement would by itself. Progesterone therefore has a unique potential as a treatment for injuries to the central nervous system, including stroke and traumatic brain injuries. 7. Progesterone is converted into a variety of metabolites with different modes of action in the repair of nervous tissue.
Fertil Steril. The value of luteal support with progesterone in gonadotropin-induced cycles. 1993 Nov; 60(5):786-90 Hamilton CJ, Jaroudi KA, Sieck UV.
2. Progesterone is one of a number of “progestins” — hormones with the properties listed above — but progesterone is safer and has fewer side effects than other progestins.
Progesterone is a hormone that regulates bodily functions in both men and women. These include cardiovascular processes, cell division, temperature control, muscle relaxation, inflammation, and fat metabolism, among others. Progesterone therefore has many areas of application, such as:.
2000 Nov; 53(5):615-20 O’Leary P, Feddema P, Chan K, Taranto M, Smith M, Evans S. Salivary, but not serum or urinary levels of progesterone are elevated after topical application of progesterone cream to pre- and postmenopausal women. Clin Endocrinol (Oxf).
Steroid Wikipedia website.
Transdermal progesterone cream for vasomotor symptoms and postmenopausal bone loss. Obstet Gynecol. 1999 Aug; 94(2):225-8 Leonetti HB, Longo S, Anasti JN.
Vasomotor symptoms consist of hot flashes or night sweats that result from sudden opening of the blood vessels close to the skin. Progesterone cream has been shown effective for preventing these symptoms. 10.
2009 Jul; 30(2):158-72 Cekic M, Sayeed I, Stein DG. Front Neuroendocrinol. Combination treatment with progesterone and vitamin D hormone may be more effective than monotherapy for nervous system injury and disease.
Estradiol replacement (ERT) has proved effective in treating and preventing these problems. Progestins act by down-regulation of estradiol receptor activity, which is an advantage for preventing endometrial hyperstimulation, but a potential disadvantage when beneficial effects of estradiol are opposed.” 12. As a result, the majority of women develop symptoms, including hot flushes, sleep disturbance, and vaginal dryness. ERT has, however, led to increased risk of endometrial carcinoma. Consequently, treatment regimens now include progestins (HRT) to protect women who have a uterus. The theory behind the use of progesterone for menopausal symptoms is well explained in an article from the Yale University School of Medicine, which states: “The failure of follicular development that characterizes the menopause leads to a marked reduction in serum levels of estradiol and progesterone. Long-term consequences of ovarian insufficiency include genital atrophy, osteoporosis, and increased rates of myocardial infarction.
[Sexual dysfunction in the menopause. Incidence, pharmacological treatment and side effects] Ugeskr Laeger. 2006 Feb 6; 168(6):559-63 Gregersen N, Hilmand CB, Jensen PT, Giraldi AG.
1994 Dec; 20(2-3):191-8 Affinito P, DiCarlo C, DiMauro P, Napolitano V, Nappi C. Endometrial hyperplasia: efficacy of a new treatment with a vaginal cream containing natural micronized progesterone. Maturitas.
Progesterone is one of the many steroid hormones made in the bodies of all animals, both male and female. “Steroid” means that its molecular structure contains a “core” pattern of 17 carbon atoms arranged in four fused rings. 1 ) Different steroid hormones are distinguished from one another by the various molecular groups which adorn the steroid core. (See the illustrations in Wikipedia.
Men, on the other hand, have a life-long relative shortage of progesterone. 3 The fact that this method has not been studied in men does not mean that it doesn’t work — it just means that the medical world is hidebound and uninterested in male esthetics. Studies in post-menopausal women has shown that the application of progesterone cream to the skin leads to improved elasticity and firmness. In women menopause results in a decline of various hormones, including progesterone.
In the U.S. Food and Drug Administration have adopted censorship as a method for intensifying their control over supplement users and their suppliers. Thus, FDA regulations prohibit us from ling you that any of our products are effective as medical treatments, even if they are, in fact, effective. and some other industrialized countries, government agencies like the U.S.
Differential effects of progestins on the brain. Maturitas. 2003 Dec 10; 46 Suppl 1:S71-5 Gruber CJ, Huber JC.
Soymilk or progesterone for prevention of bone loss—a 2 year randomized, placebo-controlled trial. Eur J Nutr. 2004 Aug; 43(4):246-57 Lydeking-Olsen E, Beck-Jensen JE, Setchell KD, Holm-Jensen T.
Usp progesterone cream (2 transdermal cream)